Todoroki K, Kawamoto T, Otsuka M, Takada Y, Atachi S, Yuzawa K,
Koike N, Yoshida S, Fukao K, Ohara K
IORT combined with resection for Stage IV gallbladder carcinoma Vaeth JM(ed): Therapy in the Treatment of Cancer　Front Radiat Ther Oncol. Karger,, 3: 165 – 172 1997
Paper list of author and co-auther
1.Suzuki H, Roa JC, Kawamoto T, Ishige K, Wistuba II, Li D, Thomas MB, Shoda J.
Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients. Molecular and Clinical Oncology 3: 464-470 2015
2.Miyahara N, Shoda J, Kawamoto T, Ishida H, Ueda T, Akimoto Y, Kawakami H, Irimura T.
Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications. Oncol Rep. 2014 32(5):1796-802
3.Kawamoto T, Ishige K, Thomas M,Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J
Overexpression and Gene Amplification of EGFR, HER2, and HER3 in Biliary Tract Carcinomas, and the Possibility for Therapy with the HER2-Targeting Antibody Pertuzumab J Gastroenterol 2014 Aug 12
4. Matsuda A, Kuno A, Matsuzaki H, Kawamoto T, Shikanai T, Nakanuma Y, Yamamoto M, Ohkohchi N, Ikehara Y, Shoda J, Hirabayashi J, Narimatsu H.
Glycoproteomics-based cancer marker discovery adopting dual enrichment with Wisteria floribunda agglutinin for high specific glyco-diagnosis of cholangiocarcinoma.
J Proteomics. 2013 85:1-11
5. Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.
Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.
J Gastroenterol. 2013 Apr 17.
6. Shoda J1, Ishige K, Sugiyama H, Kawamoto T.
Biliary tract carcinoma: clinical perspectives on molecular targeting strategies for therapeutic options.J Hepatobiliary Pancreat Sci. 2012 19:342-53.
7. Matsuda A, Kuno A, Kawamoto T, Matsuzaki H, Irimura T, Ikehara Y, Zen Y, Nakanuma Y, Yamamoto M, Ohkohchi N, Shoda J, Hirabayashi J, Narimatsu H Wisteria floribunda agglutinin-positive mucin 1 is a sensitive biliary marker for human cholangiocarcinoma. Hepatology 2010 52:174-182
8.Matsuda A, Kuno A, Ishida H, Kawamoto T, Shoda J, Hirabayashi J. Development of all-in-one technology for glycan profiling targeting formalin-embedded tissue sections. Biochem Biophys Res Commun. 2008 30;370(2):259-63
9. Ishige K, Shoda J , Kawamoto T, Matsuda S , Ueda T , Hyodo I , Ohkohchi N , Puri RK , Kawakami K Potent in vitro and in vivo antitumor activity of interleukin- 4 – conjugated Pseudomonas exotoxin against human biliary tract carcinoma. Int J Cancer. 2008 123: 2915-2922
10. Colby JKL, Klein RD, McArthur MJ, Conti CJ, Kiguchi K, Kawamoto T, Riggs PK,
Pavone AI, Sawicki J, Fischer SM Progressive Metaplastic and Dysplastic Changes in Mouse Pancreas Induced by Cyclooxygenase-2 Overexpression.
Neoplasia 2008 10 : 782–796.
11. Miyahara N, Shoda J, Ishige K, Kawamoto T, Ueda T, Takie R, Ohkohchi N, Hyodo
I, Thomas MB, Krishnamurthy S, Carraway KL , Irimura T MUC4 interacts with
ErbB2 in human gallbladder carcinoma: Potential pathobiological implications Eur J
Cancer 2008 44 :1048-56.
12. Matsuda A, Kuno A, Ishida H, Kawamoto T, Shoda J, Hirabayashi J Development of
an all-in-one technology for glycan profiling targeting formalin- embedded tissue
sections. Biochem Biophys Res Commun. 2008 370:259-63.
13. Kawamoto T, Krishnamurthy S, Tarco E, Trivedi S, Wistuba II, Li D, Roa I, Roa JC, Thomas MB HER receptor family: Novel candidate for targeted therapy for gallbladder and extrahepatic bile duct cancer. Gastrointest Cancer Res 2007 6: 221-227
14. Kiguchi K, Ruffino L, Kawamoto T, Franco E, Kurakata S, Fujiwara K, Hanai M, Rumi M, DiGiovanni J Therapeutic effect of CS-706, a specific cyclooxygenese-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. Mol Cancer Ther. 2007 6: 1709-17
15. Wu Q, Kiguchi K, Kawamoto T, Ajiki T, Traag J, Carbajal S, Ruffino L, Thames H,
Wistuba I, Thomas M, Vasquez KM, DiGiovanni J Therapeutic effect of rapamycin
on gallbladder cancer in a transgenic mouse model. Cancer Res. 2007 67: 3794-
3800
16. Kurata M, Okajima K, Kawamoto T, Uchiba M, Ohkohchi N Antithrombin reduces
reperfusion-induced hepatic metastasis of colon cancer cells. World J Gastroenterol.
2006 12: 60-65
17. Kiguchi K, Ruffino L, Kawamoto T, Ajiki T, DiGiovanni J Chemopreventive
and therapeutic efficacy of orally active tyrosine kinase inhibitors in a transgenic
mouse model of gallbladder carcinoma.. Clin Cancer Res. 2005 11: 5572 – 5580
18. Ghosh M, Kamma H, Kawamoto T, Koike N, Miwa M, Kapoor VK, Krishnani N,
Agrawal S, Ohkohchi N, Todoroki T MUC1 core protein as a marker of gallbladder
malignancy. Eur J Surg Oncol 2005 31: 891 – 896
19. Iwai T, Kudo T, Kawamoto R, Kubota T, Togayachi A, Hiruma T, Kawamoto T,
Morozumi K, Narimatsu H Core 3 synthase is down- regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. Proc.Natl. Acad. Sci. USA　2005 102: 4572-4577
20. Ghosh M, Koike N, Tsunoda S, Hirano T, Kaul S, Kashiwagi H, Kawamoto T, Ohkohchi N, Saijo K, Ohno T, Miwa M, Todoroki T
Characterization and genetic analysis in the newly established human bile duct
cancer cell lines. Int J Oncol 2005 26: 449-56
21. Kawamoto T, Shoda J, Miyahara N, Suzuki H, Furukawa M, Todoroki T,
Tanaka N, Irimura T 　Expression of MUC1 recognized by monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of carcinoma of the gallbladder. Clin Exp Metastasis 2004 21: 353-362
22. Suzuki H, Shoda J, Kawamoto T, Shinozaki E, Miyahara N, Hotta S, Iizuka Y, Nakahara A, Tanaka N, Yanaka A, Irimura T Expression of MUC1
recognized by monoclonal antibody MY.1E12 is a useful biomarker for tumor
aggressiveness of advanced colon carcinoma. Clin Exp Metastasis 2004
21: 321-329
23. Miyahara N, Shoda J, Kawamoto T, Furukawa M, Ueda T, Todoroki T, Tanaka N,
Matsuo K, Yamada Y, Kohno K, Irimura T
Expression of UDP-N-acetyl-α-D- galactosamine-polypeptide Gal Nac N-
acetylgalactosaminyl transferase isozyme 3 in the subserosal layer correlates
with postsurgical survival of pathological tumor stage 2 carcinoma of the
gallbladder. Clin.Cancer Res. 2004 10: 2090-2099
24. Nozue M, Oshima Y, Taniguchi H, Kawamoto T, Todoroki T, Fukao K
Progressive sigmoidectomy for cancer during the last 24 years in our
department. Hepatogastroenterology 2004 51: 1337-1340
25. Shinozaki E, Adachi S, Shoda J, Kawamoto T, Suzuki H, Irimura T, Ohkohchi N 　Subcellular localization of MUC1 recognized by a monoclonal antibody MY.1E12 correlates with postsurgical prognosis in differentiated type gastric carcinomas of stage II and III Int J Oncol 2004 25: 1257-1265
26. Ghosh M, Koike N, Yanagimoto G, Tsunoda S, Kaul S, Hirano T, Emura F,
Kashiwagi H, Kawamoto T, Ohkohchi N, Saijou K, Ohno T, Miwa M, Todoroki T Establishment and characterization of unique human gallbladder cancer cell lines.
Int. J. Oncol. 2004 24: 1189-1196
27. Nozue M, Taniguchi H, Kawamoto T, Koike N, Shinozaki E, Adachi S,
　　Todoroki T, Fukao K Refractory proctosigmoiditis probably caused by
　　inferior mesenteric vein ligation at sigmoidectomy. Hepatogastroenterology 　
2004 51: 980-982
28. Todoroki T, Koike N, Morishita Y, Kawamoto T, Ohkohchi N, Shoda J, Fukuda Y, Takahashi H Patterns and predictors of failure after curative resections of carcinoma of the ampulla of Vater. Ann. Surg. Oncol. 2003 10: 1176-1183
29. Nakagawa Y, Todoroki T, Kondo T, Kawamoto T, Ohkohchi N, Ohara K
A salvage treatment for solid liver metastasis after radical resection of Klatskin
tumour. HPB 2003 5: 254-257
30. Shoda J, Suzuki H, Sugiyama Y, Hirouchi M, Utsunomiya H, Oda K, Kawamoto T, Matsuzaki Y, Tanaka N Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome. Hepatol. Res. 2003 27: 322-325
31. Shoda J, Ueda T, Kawamoto T, Todoroki T, Asano T, Sugimoto Y, Ichikawa A, Maruyama T, Nimura Y, Tanaka N Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological significance for cholangitis.
Clin Gastroenterol Hepatol 2003 1: 285-296
32. Liengswangwong U, Nitta T, Kashiwagi H, Kikukawa H, Kawamoto T,
　 Todoroki T, Uchida K, Khuhaprema T, Karalak A, Srivatanakul P, Miwa M 　　　
Infrequent microsatellite in stability in liver fluke infection-associated intrahepatic
cholangiocarcinomas from Thailand. Int. J. Cancer 2003 107: 375-380
33. Emura F, Kamma H, Ghosh M, Koike N, Kawamoto T, Saijou K, Ohno T, Ohkouchi N, Todoroki T Establishment and characterization of novel xenograft models of human biliary tract carcinomas. Int J Oncol 2003 23: 1293-1300
34. Adachi S, Inagawa S, Enomoto T, Shinozaki E, Oda T, Kawamoto T
　 Subjective and functional results after total gastrectomy: prospective study for longterm comparison of reconstruction procedures. Gastric Cancer 2003 6: 24-29
35. Gunji N, Miyamoto H, Orii K, Kawamoto T, Fukao K Pancreatic carcinoid: transcatheter arterial chemoembolization of liver metastasis. 　　　Hepatogastroenterology 2003 50: 2166-2168
36. Enomoto T, Todoroki T, Koike N, Kawamoto T, Matsumoto H 　　　Xanthogranulomatous cholecystitis mimicking stage IV gallbladder cancer. Hepatogastroenterology 2003 50: 1255-1258
37. Ishiguro S, Takada Y, Gu M, Fukunaga K, Taniguchi H, Seino K, Kawamoto T,
Yuzawa K, Otsuka M, Todoroki T, Fukao K Auxiliary partial orthotopic liver transplantation for fulminanat hepatitis: regeneration of the diseased native liver in a pig model. Transplantation 2003 75: 1901-1904 　　　
38. Inagawa S, Itabashi M, Adachi S, Kawamoto T, Hori M, Shimazaki J, Yoshimi F, Fukao K 　Expression and prognostic roles of [beta]-catenin in hepatocellular carcinoma: Correlation with tumor progression and postoperative survival.
Clin. Cancer Res. 2002 8 : 450-456
39. Kawamoto T, Shoda J, Asano T, Ueda T, Furukawa M, Koike N, Tanaka N, Todoroki T, Miwa M Expression of cyclooxygenase-2 in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder
Int. J. cancer 2002 98: 427-434
40.Asano T, Shoda J, Ueda T, Kawamoto T, Todoroki T, Shimonishi M, Tanabe T,
Sugimoto Y, Ichikawa A, Mutoh M, Tanaka N, Miwa M 　Expressions of
cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder:
crucial role of arachidonate metabolism in tumor growth and progression.
Clin. Cancer Res. 2002 8: 1157-1167
41. Nozue M, Oshiro Y, Kurata M, Seino K, Koike N, Kawamoto T, Taniguchi H, Todoroki T, Fukao K Treatment and prognosis in colorectal cancer patients with bone metastasis. Oncol. Rep. 2002 9: 109-112
42. Kanazawa N, Oda T, Gunji N, Nozue M, Kawamoto T, Todoroki T, Fukao K
E-cadherin expression in the primary tumors and metastatic lymph nodes of poorly differentiated types of rectal cancer. Surg. Today 2002 32: 123-128
43. Nozue M, Isaka N, Maruyama, Kawamoto T, Seino KI, Taniguchi H, Fukao K Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil Oncol Rep. 2002 9: 93-96
44. Kawamoto T, Shoda J, Irimura T, Miyahara N, Furukawa M, Ueda T, Asano T,
Kano M, Koike N, Fukao K, Tanaka N, Todoroki T
Expression of MUC1 mucins in the subserosal layer correlates with postsurgical
prognosis of pathological tumor stage 2 carcinoma of the gallbladder
Clin. Cancer Res. 2001 7: 1333-1342
45. Inagawa S, Hori M, Shimazaki J, Matsumoto S, Ishii H, Itabashi M, Adachi S,
Kawamoto T, Fukao K Solitary schwannoma of the colon: Report of two cases
Surgery Today　2001 31: 833-838
46. Inagawa S, Shimazaki J, Hori M, Yoshimi F, Adachi S, Kawamoto T, Fukao K,
Itabashi M Hepatoid adenocarcinoma of the stomach.
　Gastric Cancer 2001 4: 43-52
47. Todoroki T, Kawamoto T, Koike N, Fukao K, Shoda J, Takahashi H
Treatment strategy for patients with middle and lower third bile duct cancer　 Br J Surg 2001 88: 364-370
48. Takada Y, Otsuka M, Seino K, Taniguchi H, Koike N, Kawamoto T,
Koda K, Adachi S, Yuzawa, K, Nozue M, Todoroki T, Fukao K
Hepatic resection for metastatic tumors from noncolorectal carcinoma Hepatogastroenterology 2001 48: 83-86
49. Oshima Y, Nozue M, Taniguchi H, Seino KI, Koike N, Kawamoto T, Todoroki T, Fukao K Transition and improvement in surgical treatment for rectal cancer during the last 21 years in our department. 　　　 Int. J. Oncol. 2001 19: 1283-1286
50. Ghosh M, Kawamoto T, Koike N, Fukao K, Yoshida S, Kashiwagi H, Kapoor VK, Agarwal S, Krishnani N, Uchida K, Miwa M, Todoroki T Cyclooxygenase expression in the gallbladder
Int J Mol Med 2000 6 : 527-532
51. Todoroki T, Kawamoto T, Koike N, Takahashi H, Yoshida S, Kashiwagi H, Takada Y, Otsuka M , Fukao K Radical resection of hilar bile duct carcinoma and predictors of survival　Br J Surg 2000 87: 306-313
52. Adachi S, Kawamoto T, Otsuka M, Todoroki T , Fukao K
Enteral vitamin B12 supplements reverse postgastrectomy B12 deficiency Ann Surgery 2000 232 : 199-201
53. Koike N, Todoroki T, Kawamoto T, Inagawa S, Yoshida S, Fukao K
Amputation neurinoma mimics common hepatic duct carcinoma Heptogatroenterology 2000 47 : 639-643
54. Inagawa S, Adachi S, Oda T, Kawamoto T, Koike N, Fukao K
Effect of fat volume on postoperative complications and survival rate after D2 dissection for gastric cancer Gastric Cancer 2000 3 : 141-144
55. Todoroki T, Kawamoto T, Koike N, Takahashi H, Yoshida S, Kashiwagi H, Takada Y, Otsuka M, Fukao K Radical resection of hilar bile duct carcinoma and predictors of survival Br J Surg 2000 87: 306-313
56. Todoroki T , Ohara K, Kawamoto T, Koike N , Yoshida S, Kashiwagi H, Otsuka M, Fukao K Benefits of adjuvant radiotherapy after radical resection of locally advanced main hepatic duct carcinoma. Int J Radiat Oncol Biol Phys 2000 46: 581-587
57. Todoroki T, Kawamoto T, Takahashi H, Takada Y, Koike N, Otsuka M, Fukao K Treatment of gallbladder cancer by radical resection Br J Surg 199986: 622-627
58. Todoroki T, Kawamoto T, Otsuka M, Koike N, Yoshida S, Takada Y, Adachi S , Kashiwagi H, Fukao K, Ohara K
Benefits of combining radiotherapy with aggressive resection for stage IV gallbladder cancer Hepatogastroenterology 1999 46: 1585-1591
59. Todoroki T, Takahashi H, Koike N, Kawamoto T, Kondo T, Yoshida S, Kashiwagi H, Otsuka M, Fukao K, Saida Y Outcome of aggressive treatment of stage IV gallbladder cancer and predictors of survival Hepatogastroenterology 1999 46: 2114-2121
60. Fukunaga K, Todoroki T, Takada Y, Otsuka M, Kawamoto T, Fukao K
Hepatic functional reserve in patients with biliary malignancies; an assessment by technetium 99m galacosyl human serum albumin hepatic scintigraphy Int Surg 1999 84: 199-203
61. Gunji N, Oda T, Todoroki T, Kanazawa N, Kawamoto T, Yuzawa K, Scarpa A,
Fukao K Pancreatic carcinoma correlation between E-cadherin and α-catenin
expression status and liver metastasisCancer 1998 82: 1649-1656　
62. Koike N, Todoroki T, Kawamoto T, Yoshida S, Kashiwagi H, Fukao K, Ohno T, Watanabe T The invasion potentials of human biliary tract carcinoma cell lines :
correlation between invasiveness and morphologic characteristics
Int J Oncol 1998 13:1269-1274
63. Koike N, Saitoh K, Todoroki T, Kawamoto T, Iwasaki Y, Nakamura K
Cell proliferation kinetics of the bile duct epithelium of the rat.
Cell Prolif. 1993 26: 183-193
64. Todoroki T, Fukuda Y, Kawamoto T, Saida Y, Ohara K, Iwasaki Y, Matsuzaki O Long-term survivors after salvage surgery combined with radiotherapy for recurrence of stage IV main hepatic duct cancer – Report of two cases Hepatogastroenterology Current medical and Surgical Trends 1993 3: 285-293
65. Nozue M, Koike N, Kawamoto T, Toko, K ,Sindou T, Orii K, Kondou T, Mun Y, Nitou M, Todoroki T, Dependence of the thymidylate synthase inhibition rate on the interval after the last administration of tegafur in sigmoid colon cancer patients.
J Surg Oncol 1993 52: 115-118
66. Todoroki T, Iwasaki Y, Orii K, Otsuka M, Ohara K, Kawamoto T, Nakamura K
Resection combined with itraoperative radiation therapy (IORT) for stage IV(TNM) gallbladder carcinoma World J Surg 1991 15: 357-366
Overseas Recruitment and Plenary Speech
3rd International Postgraduate Course
Hepato Pancreatico Biliary Disease To-day KKU-IGSC Joint Project 2000 Jan
“Immuno Histochemical Expression of Cyclooxygenase in Diseased Biliary Tract”
2006 ASCO Annual Meeting（Atlanta）

Plenary session
GASTROINTESTINAL (NONCOLORECTAL) CANCER
Amplification of HER-2/neu (erbB2) gene expression in gallbladder (GBC) and in bile duct cancer (BDC) (biliary tract cancer, BTC)
T. Kawamoto , M. Thomas , E. Tarco , S. Trivedi , I. Wistuba , S. Krishnamurthy