PFC-FD stands for “Platelet-derived Factor Concentrate Freeze Dry,” which in Japanese is “Kesshoubann-yurai-innshi-noushukubutu-touketsu-kannsou”. It essentially is a regenerative therapy that utilizes the self-repairing function of the patient’s own blood, not unlike the PRP therapy described above, but the critical difference is that PFC-FD does not contain platelets. Instead, cytokines are concentrated twice as much, and anti-inflammatory and tissue repair effects are expected to be more effective. PFC-FD is injected into the injured area to promote self-repair function, reducing pain and healing the injured area. The general advantage of this treatment is that there are fewer side effects, such as allergies, because it injects an ingredient extracted from the patient’s own platelets. In addition, while PRP cannot be frozen and stored, PFC-FD can be frozen and stored for approximately 6 months, allowing for treatments whenever desired. However, because it takes three weeks from blood drawing to purification, treatment cannot be performed on the same day as PRP therapy (which takes about 1.5 hours for purification). The disadvantage is that some cytokines induce an inflammatory response, so there is no direct harm, although common side effects (pain, redness, swelling, etc.) from injections may occur. In addition, because it depends on self-repair, the repair process may not work well, and there are individual differences regarding the effectiveness of its treatment.