Cancer screening
Cancer screening at Forest of Regeneration Clinic Roppongi
Features: Covers those who have tested positive for amino index or nematode cancer, those who are young but have a family history of cancer and are worried about cancer, and those who have or have had cancer at a different age. In response to the growing demand for cancer screening, our hospital has created the Forest of Regeneration Whole Body Cancer Screening Course, which combines cancer genetic testing, MRI testing using the DWIBS method, and CT testing.
The DWIBS method is a new testing method developed by a Japanese doctor in 2004 as MRI became more sophisticated. Generally, cancer cells have a high cell density, and the movement between cells is slow, which is used to detect and analyze the movement using MRI to diagnose cancer. PET-CT detects and diagnoses cancer by utilizing the fact that cancer cells have a higher sugar metabolism than normal cells, so the mechanism is different from the DWIBS method.
Comparison of DWIBS method and PET-CT
| Comparison items | PET-CT | DWIBS |
|---|---|---|
| Dietary restrictions before testing | Fast from approximately 4 to 5 hours before the test time. Do not drink sugary drinks such as juice or milk, or alcohol. | Nothing in particular |
| injection | Administer test drug FDG (radioactive substance) | Nothing |
| medical exposure | Yes (double exposure to X-rays and FDG, although the amount is not enough to cause concerns about side effects) | Nothing |
| Shooting time | Around 30 minutes | Around 30 minutes |
| resting time | Before the test: About 1 hour for the test drug to spread throughout the body / After the test: About 30 minutes to 1 hour to attenuate the radioactive material (about 3 hours in total) | Nothing |
| Precautions for medical examination | Those who are pregnant or have kidney disease are not allowed to visit the clinic. Consultation is required if you have high blood sugar levels or are undergoing diabetes treatment (test results may not be accurate) | Patients with metal plates in their body, pacemaker users, tattoos, etc. cannot be examined. |
| Time required from reception to completion | 2-3 hours | 1-1.5 hours |
| weak points | stomach, urinary system, etc. | Stomach, esophagus, large intestine, thyroid, lungs, etc. * |
Cancer gene testing(CanTect)
CanTect analyzes the current status of cancer-related genes, quantifies the risk of cancer, and can be used to prevent cancer, confirm the effectiveness of cancer treatment, and prevent recurrence.
Analysis of cancer gene expression
We will select 47 genes that are highly associated with cancer development and measure their messenger RNA levels. At present, it only evaluates the susceptibility to cancer, and it seems difficult to identify individual cancers.
Free DNA concentration
Cell death occurs frequently in cancer tissues even without any treatment, and a large amount of DNA from dead cells flows into the bloodstream, resulting in an increase in the concentration of free DNA compared to healthy individuals. Therefore, higher concentrations increase the risk of cancer development.
Mutation analysis
DNA constantly mutates due to external stimuli (ultraviolet rays, chemicals, active oxygen, etc.), but if a mutation is found in the DNA of a tumor suppressor gene, the DNA repair mechanism and immunity weaken, and the mutation occurs. Genes are not removed, which promotes the development and proliferation of cancer cells.
Methylation analysis
When a phenomenon called methylation occurs in a tumor suppressor gene, which turns off its function, it becomes impossible to suppress cancer development. If two or more methylated tumor suppressor genes are present, cancer is suspected.
Based on these results, we will promote screening of organs that are susceptible to cancer. For patients diagnosed with C or D, we provide lifestyle guidance centered on diet to prevent the onset or progression of cancer, as well as recurrence after cancer treatment.
