Autologous NK cell + allogeneic NK cell exosome combination therapy
Cancer treatment using NK cells is an immunotherapy that increases the attack power against cancer cells by collecting lymphocytes from the patient’s own blood, culturing them using interleukin (IL)-2, etc., expanding NK cells and NKT cells, adding a strong NK activation function, and injecting them into the body. This treatment aims to help eliminate cancer cells and can be used in conjunction with conventional chemotherapy and radiation therapy.

Treatment mechanism
• Role of NK cells
NK (natural killer) cells are innate immune cells that find, attack, and destroy cancer and virus-infected cells.
• Treatment flow:
1. Collect patient’s blood and isolate NK cells.
2. Activate NK cells in a dedicated facility and multiply them from hundreds of millions to billions.
3. The activated NK cells are returned to the patient’s body via an intravenous drip.

• Effects:
Activated NK cells are expected to attack cancer cells through circulation in the body, suppressing cancer growth or reducing cancer size. It is also expected to be effective in preventing recurrence and metastasis after surgery.

Features and expected effects
• Fewer side effects: Because it uses your own immune cells, it is said to have fewer side effects than transplanting someone else’s cells.
• Combination with other treatments: Synergistic effects can be expected when combined with other treatments such as chemotherapy and radiation therapy.
• Cancer prevention: With permission from the Ministry of Health, Labor and Welfare, it can also be used to replenish NK cells for cancer prevention.
At our hospital, in order to further increase the activity of NK cells, we inject exosomes secreted by NK cells intravenously to enhance the antitumor effect. It is expected to be more effective than conventional NK cell therapy, so we believe it is suitable for patients whose cancer is more advanced and whose immune system is weakened.

The progress of an example is shown below.